Consultez les derniers articles autour de la maladie de Willebrand

Dernière mise à jour : Vendredi 03 février 2023

Approach to Bleeding in the Hospitalized Patient

Excessive bleeding is relatively common in adult inpatients, whether as the primary reason for admission or developing during the hospital stay. Common causes include structural issues, medication effects...
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Blood 2023; aop:10.1182/blood.2021014766
Samuelson Bannow, Bethany et al.

Challenges in the management of women with type 2B von Willebrand disease during pregnancy and the postpartum period: evidence from literature and data from an international registry and physicians' survey-communication from the Scientific and Standardization Committees of the International Society on Thrombosis and Haemostasis

Management of women with type 2B von Willebrand disease (VWD) during pregnancy is challenging because of dysfunctional von Willebrand factor (VWF) and the complexity resulting from discrepant VWF/factor...
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Journal of Thrombosis and Haemostasis, December 14, 2022
Predrag Miljic et al.

Special considerations in GI bleeding in VWD patients.

Gastrointestinal (GI) bleeding is an important cause of morbidity and mortality in von Willebrand disease (VWD). It has been noted that GI bleeding caused by angiodysplasia is overrepresented in VWD patients...
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Hematology. American Society of Hematology. Education Program 2022 Dec; 2022(1): 624-630
Chornenki Nicholas L J et al.

Structure and dynamics of the von Willebrand Factor C6 domain.

Von Willebrand disease (VWD) is a bleeding disorder with different levels of severity. VWD-associated mutations are located in the von Willebrand factor (VWF) gene, coding for the large multidomain plasma protein VWF with essential roles in hemostasis and thrombosis. On the one hand, a variety of mutations in the C-domains of VWF are associated with increased bleeding upon vascular injury. On the other hand, VWF gain-of-function (GOF) mutations in...
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Journal of structural biology 2022 Dec; 214(4): 107923
Chen Po-Chia et al.

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