Actualités

Consultez les derniers articles autour de la maladie de Willebrand.

Dernière mise à jour : Vendredi 12 août 2022

Longitudinal bleeding assessment in von Willebrand disease utilizing an interim bleeding score

Standardized methods to reassess bleeding in von Willebrand disease (VWD) are currently lacking. To address this issue we adapted the International Society on Thrombosis and Haemostasis bleeding assessment...
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Journal of Thrombosis and Haemostasis 2022; AOP: 10.1111/jth.15807
Michelle Lavin et al.

Genetic Alterations, DNA Methylation, Alloantibodies and Phenotypic Heterogeneity in Type III von Willebrand Disease.

Type III von Willebrand disease is present in the Punjab province of Pakistan along with other inherited bleeding disorders like hemophilia. Cousin marriages are very common in Pakistan so genetic studies...
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Genes 2022 May; 13(6)
Naveed Muhammad Asif et al.

Continuous Infusion of Factor VIII and von Willebrand Factor in Surgery: Trials with pdFVIII LFB or pdVWF LFB in Patients with Bleeding Disorders

A plasma-derived factor VIII product (pdFVIII, Factane 100 or 200 IU/mL) and a plasma-derived von Willebrand factor product (pdVWF, Wilfactin 100 IU/mL) are approved for replacement therapy by intravenous...
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Thrombosis and haemostasis 2022 May

Importance of Genotyping in von Willebrand Disease to Elucidate Pathogenic Mechanisms and Variability in Phenotype

Genotyping is not routinely performed at diagnosis of von Willebrand disease (VWD). Therefore, the association between genetic variants and pathogenic mechanism or the clinical and laboratory phenotype is unknown in most patients, especially in type 1 VWD. To investigate whether genotyping adds to a better understanding of the pathogenic mechanisms and variability in phenotype, we analyzed the VWF gene in 390 well-defined VWD patients, included in...
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Hemasphere 2022 May

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