La dernière actualité médicale WillebrandXPERT
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WillebrandXPERT
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Publications du  Mercredi 03 décembre 2025
A novel cause of type 1 von Willebrand disease: impaired exocytosis of Weibel-Palade bodies due to biallelic MADD variants
Blood 2025; 146(17): 2133-44
The regulated secretion of von Willebrand factor (VWF) from Weibel-Palade bodies (WPBs) in endothelial cells is fundamental to hemostasis. This process relies on recruiting Rab GTPases and their effectors...
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Von Willebrand factor and von Willebrand disease in ageing: mechanisms, evolving phenotypes, and clinical implications
The Lancet Haematology 2025; 12(11): e908-e917
The global population is ageing and this demographic shift has profound effects on haemostasis, notably a progressive tilt towards a hypercoagulable state. A major age-associated change in haemostasis...
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High Rates of Post-Tonsillectomy Hemorrhage in ChildrenWith von Willebrand Disease
Pediatric Blood & Cancer (2025).
Though tonsillectomies are commonly performed in children, the rate of post-tonsillectomy hemorrhage in those with von Willebrand disease (VWD) is unknown. Objectives: To determine the rate of post-tonsillectomy...
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Treatment of von Willebrand Disease.
Blood advances 2025 Nov
Treatment for von Willebrand disease (VWD), the most common inherited bleeding disorder, has advanced considerably since its initial description by Erik von Willebrand first described a family in the Åland...
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