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Von Willebrand Academy - Ep.4
Publications on  Friday September 25, 2026
A phase 1, open-label study to assess the pharmacokinetics, safety, and tolerability of a single intravenous injection of efanesoctocog alfa in adults with type 2N or type 3 von Willebrand disease
Journal of Thrombosis and Haemostasis 2026; 24(1): 79-87
Efanesoctocog alfa is a high-sustained factor (F)VIII replacement therapy for hemophilia A. The D'D3 domain of efanesoctocog alfa overcomes the von Willebrand factor–imposed half-life ceiling and...
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Prevention of hemorrhage after implantation of mechanical circulatory support with a purified von Willebrand factor concentrate: results of the early terminated randomized controlled trial
Journal of Thrombosis and Haemostasis 2026; 24(2): 408-17
Bleeding complications are frequent under left ventricular assist device (LVAD) support. LVAD-associated high shear stress induces increased proteolysis of circulating von Willebrand factor (VWF), which...
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Factor VIII and von Willebrand factor activity levels during long-term prophylaxis with wilate—Analyses from the WIL-31 study
Research and Practice in Thrombosis and Haemostasis 2026; 10(1): 103327
Long-term von Willebrand factor (VWF) prophylaxis is recommended for people with von Willebrand disease (VWD) who experience frequent and severe bleeds. However, repeated administration of VWF-containing...
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Pregnancy outcomes in women with Von Willebrand disease: a statewide cohort study
Research and Practice in Thrombosis and Haemostasis 2026; 10(2): 103383
Multiple studies conducted between 1990s and 2010s reported increased rates of postpartum hemorrhage (PPH) among women with von Willebrand disease (VWD), even with specialized peripartum care. To generate...
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