The regulated secretion of von Willebrand factor (VWF) from Weibel-Palade bodies (WPBs) in endothelial cells is fundamental to hemostasis. This process relies on recruiting Rab GTPases and their effectors...
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The global population is ageing and this demographic shift has profound effects on haemostasis, notably a progressive tilt towards a hypercoagulable state. A major age-associated change in haemostasis...
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Though tonsillectomies are commonly performed in children, the rate of post-tonsillectomy hemorrhage in those with von Willebrand disease (VWD) is unknown. Objectives: To determine the rate of post-tonsillectomy...
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Treatment for von Willebrand disease (VWD), the most common inherited bleeding disorder, has advanced considerably since its initial description by Erik von Willebrand first described a family in the Åland Islands with severe bleeding. Infusion of von Willebrand factor (VWF) containing concentrates continue to serve as the foundation of management in addition to desmopressin, hormonal therapies, and antifibrinolytic agents such as tranexamic...
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