Consulte los últimos artículos sobre la enfermedad de von Willebrand
Última actualización: Jueves, 06 de febrero de 2025While bleeding around pregnancy is well described in von Willebrand disease (VWD), the risk of pregnancy loss is less certain. We aimed to describe the frequency of pregnancy loss in females with VWD compared...
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New treatments for patients with bleeding disorders (PWB) have emerged, including products with extended half-life and subcutaneous administration. These less frequent treatments can potentially enhance...
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The clinical management of the inherited bleeding disorder von Willebrand disease (VWD) focuses on normalizing circulating levels of von Willebrand factor (VWF) and factor VIII (FVIII) to prevent or control...
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Treatment options for the bleeding disorder von Willebrand disease type 2B (VWD2B) are insufficient and fail to address the negative effects of circulating mutant von Willebrand factor (VWF). The dominant-negative nature of VWD2B makes functionally defective VWF an interesting therapeutic target. Previous in vitro studies have demonstrated the feasibility of allele-selective silencing of mutant VWF using small interfering RNAs (siRNAs) targeting...
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