The occurrence of unexplained severe bleeding, especially in childhood, can be related to coagulation pathway disorders, associated or not with maltreatment. In such cases of severe bleeding or intracerebral...
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People with a severe von Willebrand disease (VWD) bleeding phenotype experience frequent, prolonged and excessive mucocutaneous bleeding, such as epistaxis, gingival or gastrointestinal (GI) bleeding,...
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Type 3 von Willebrand disease (VWD), an inherited blood disorder, is caused by a total deficiency of von Willebrand factor (VWF), associated to very low levels of factor VIII (FVIII) [1]. Bleeding manifestations...
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Von Willebrand factor (VWF) has an important function in primary haemostasis by mediating the adhesion and aggregation of platelets at the site of injury. Von Willebrand disease (VWD) is caused by a deficiency of VWF and is characterized by a heterogeneous bleeding phenotype. The disease is categorized into three types: VWD with reduced VWF levels (type 1), dysfunctional VWF (type 2) or absence of VWF (type 3). The objective severity classification...
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